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. 2018 Aug 7;9:640. doi: 10.3389/fneur.2018.00640

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Copyright © 2018 Kochanek, Dixon, Mondello, Wang, Lafrenaye, Bramlett, Dietrich, Hayes, Shear, Gilsdorf, Catania, Poloyac, Empey, Jackson and Povlishock.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall strategy for therapy development using target engagement biomarkers to aid in screening prior to advancing to definitive studies of long term outcome.