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. 2018 Aug 7;9:306. doi: 10.3389/fgene.2018.00306

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Copyright © 2018 Malinovskaya, Ershova, Golimbet, Porokhovnik, Lyapunova, Kutsev, Veiko and Kostyuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Replicative senescence of cultivated skin fibroblasts derived from five donors with known parameters of the ribosomal gene arrays. (A) rDNA content for the fifth and last passages of each of the five cell lines. (B) The methylation index M for the fifth and last passages of each of the five cell lines. Each value of the index M and rDNA CN represent the average of three independent experiments. (C) The scheme describing the loss of hypermethylated DNA copies with aging. We considered, as an example, a hypothetical genome containing 400 copies of rDNA.