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. 2018 Aug 7;9:853. doi: 10.3389/fphar.2018.00853

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Copyright © 2018 Lou, Xia, Wang, Kong, Yao, Dong, Zhou and Tsim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of YPFS_+GF promoting YPFS-induced sensitized effect on DDP-treated A549/DDP cells. YPFS_+GF suppresses the WT1/MVP axis in YPFS+DDP-treated A549/DDP cells, consequently increases the intracellular concentration of DDP, as well as inhibition on mTORC2/AKT axis. Finally, YPFS_+GF promotes the sensitized effect of YPFS in DDP-treated A549/DDP cells.