Table 1.

Deviations (Å) of central atoms of TTX-binding functional groups in homology models and NavPaS from matching atoms in the Nav1.4 cryo-EM structure.

Residue	Model/structure
	Lipkind and Fozzard, 2000	Tikhonov and Zhorov, 2005a	Tikhonov and Zhorov, 2012	NavPaS
Y1p51	3.7	6.1	2.2	0.5
E1p53	10.3	8.1	2.4	0.7
E2p53	5.4	4.6	3.9	2.7
D3p54	4.6	6.6	6.1	2.4
D4p53	8.8	9.5	2.3	0.8
D1p50	4.2	3.0	4.4	2.0
E2p50	2.9	2.7	1.9	0.8
K3p50	1.1	1.6	1.5	2.0
A4p50	1.7	2.1	1.4	0.4