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. 2017 Dec 10;8(4):602–614. doi: 10.1016/j.apsb.2017.10.004

Figure 5.

Fig. 5

PVP/PTX-SAs significantly inhibit proliferation of breast cancer cells. (A) Breast cancer cells (MCF7 and MDA-MB-231, 5000 cells/well) were plated in 96-well plate and were treated with PTX or PVP/PTX-SA at a range of concentration 1–20 nmol/L for 48 h. Cell viability was assessed by MTS assay by measuring absorbance at 490 nm using microplate reader. Relative cell viability was measured (using GraphPad Prism 5 Software) with control (untreated) breast cancer cells, considering as 100%. Data represented as mean ± standard error of the mean (n = 3), *P<0.05. (B) Representative phase contrast microscopic images were captured by EVOS® FL Imaging System to evaluate the effect of PVP/PTX-SAs on the cell morphology. PTX or PVP/PTX-SA concentration was equivalent to 5 PTX nmol/L. Bar equals to 200 μm.