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. 2017 Dec 10;8(4):602–614. doi: 10.1016/j.apsb.2017.10.004

Figure 7.

Fig. 7

Preferential cell death induced by PVP/PTX-SAs in MDA-MB-231 cells. (A) Tubulin stabilization images of polyvinylpyrrolidone paclitaxel self-assembly. Cells have been treated with equivalent concentrations of 5 nmol/L PTX or PVP/PTX-SA for 8 h. Imaged by Carl Zeiss LSM 710. Original magnification 400×. This data suggests PVP/PTX-SA treatment leads to PTX-induced microtubule stabilization. (B) MDA-MB-231 cells were treated with 10 nmol/L PVP/PTX-SAs or PTX or respective controls for 48 h. Cell lysates were analyzed to detect levels of Bax, Bid, cleaved caspase 7, cleaved PARP, Bcl-xL, and MDR1, with β-actin as a control. (C) Densitometry analysis of Bid, Bax, cleaved caspase 7, cleaved PARP, Bcl-xL, and MDR1 in MDA-MB-231 cells after 48 h treatment with 10 nmol/L PVP/PTX-SAs or PTX and their respective controls. The results were consistent in two independent sets of experiments.