Table 1.
Comparison of cingulum bundle (CB) lesion effects in rats with other, related brain sites. Symbols: * results from same study as cingulum bundle lesion; √, no lesion effect; X, mild/borderline effect; XX, clear deficit; XXX, severe deficit. Numbers in parenthesis show the number of cingulum lesions in each hemisphere. In two studies (Neave et al., 1996, 1997) there were two groups with cingulum bundle lesions, which differed in the number of lesion placements per hemisphere (one, CB1 or two, CB2). In both studies, the lesions were placed asymmetrically to avoid bilateral cortical damage.
| Task | Cingulum Bundle study | Cingulum Bundle | Retrosplenial. Cortex | Anterior Thalamic Nuclei | Fornix | Anterior Cingulate |
|---|---|---|---|---|---|---|
| Water-maze reference acquisition | Warburton et al. 1998 (2) | X | X1 X6 | XXX2 | XX* XX2 XXX12 | X* |
| Harker and Whishaw 2004 (1) | X | X* | ||||
| Water-maze working | Harker and Whishaw 2004 (1) | X | X* X1 | XXX15 | XXX14 | |
| T-maze alternation acquisition | Aggleton et al. 1995 (3) | XXX | √* (ant +post cingulate) X8 √10 | XXX3 XXX7 | XXX* XXX7 | √10 X13 marginal |
| Neave et al. 1996 (2,1) | X CB2 X CB1 | |||||
| Neave et al. 1997 (2,1) | XX CB2 √ CB1 | XXX* | ||||
| Warburton et al. 1998 (2) | X | XXX* | ||||
| T-maze alternation delays | Aggleton et al. 1995 (3) | XX | √* (ant +post cingulate) √10 | XX3 XXX4 | XXX3,4 | √10 |
| Neave et al. 1996 (2,1) | √ CB2 √ CB1 (X when groups combined) | |||||
| Cross-maze alternation | Neave et al. 1997 (2,1) | √ CB2 √ CB1 | XXX4 | XXX* | ||
| Delayed nonmatch to position in operant box | Aggleton et al. 1995 (3) | √ | √* (ant +post cingulate) | XX5 | XX* | √10 |
| Neave et al. 1996 (2,1) | √ CB2 √ CB1 | |||||
| Lever discrimination and reversals | Aggleton et al. 1995 (3) | √ | √* (ant +post cingulate) | XX* | √10 | |
| Radial arm maze (working) | Neave et al. 1997 (2,1) | XX CB2 √ CB1 | XX6 | XXX9 | XXX* | √11 |
| Object recognition | Ennaceur et al. 1997 (3) | √ | √* √6 | √2 | √* | √* |
| Object location recognition | Ennaceur et al. 1997 (3) | √ | XX* (ant +post cingulate) | XX* |
The superscript numbers refer to appropriate comparison studies: 1. later reanalysis in Vann et al., 2003: 2. Warburton and Aggleton, 1999: 3. Aggleton et al., 1995: 4. Warburton et al., 1997: 5. Aggleton et al., 1991: 6. Vann and Aggleton, 2002: 7. Warburton et al., 1999: 8. Nelson et al., 2015: 9. Aggleton et al., 1996: 10. Neave et al., 1994: 11. Ragozzino et al., 1998: 12. Sutherland and Rodriguez, 1989: 13. Sánchez-Santed et al., 1997: 14. Cassel et al., 1998: 15. Perry et al., 2018.