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. 2018 Aug 7;9:648. doi: 10.3389/fneur.2018.00648

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Copyright © 2018 Wang, Zhu, Liu, Han, Lang, Gao, Lu, Wang, Hou, Zheng, Wang, Chen, Zhang, Zhang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased BBB permeability was associated with more severe disease course. (A) Patients in the increased BBB permeability group suffered a more severe disease course. The median of EDSS score of the increased BBB permeability group was 5.5 with IQR of 4.5–7.0, while was 4.5 with IQR of 2.25–6 in the normal BBB permeability group (p = 0.028). Additionally, the increased BBB permeability group had significantly higher sensory functional score, bowel/bladder functional score and ambulation score (4 with IQR of 4-4, 1 with IQR of 1-3 and 4 with IQR of 1-10 vs. 4 with IQR of 0-4, 0 with IQR of 0-1, 1 with IQR of 0-6.25, p = 0.038, 0.001, 0.036). ^*p < 0.05, ^**p < 0.01. (B–E) The albumin index was positively correlated to sensory functional score, bowel/bladder functional score, ambulation score and EDSS score (r = 0.372, p = 0.002; r = 0.420, p = 0.000; r = 0.434, p = 0.000; r = 0.449, p = 0.000).