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. 2018 Aug 7;9:648. doi: 10.3389/fneur.2018.00648

Figure 2.

Figure 2

Elevated BBB permeability was associated with higher anti-AQP4-IgG levels. (A) The BBB permeability was increased in the AQP4+ group. The mean of albumin index in the AQP4+ group was 9.15 (× 10−3) with SD of 6.26 (× 10−3), while 6.50 (× 10−3) with SD of 4.92 (× 10−3) in the AQP4- group. (B) Anti-AQP4-IgG titer was higher in serum than in CSF. For all 69 enrolled patients, the median anti-AQP4 IgG titers were 1.5 with IQR of 1-2, and 1 with IQR of 0-1.5 in serum and CSF (p = 0.000). In the increased BBB permeability group, the median serum and CSF anti-AQP4-IgG titers were 1.5 with IQR of 1-2 and 1 with IQR of 0.5-1.875 (p = 0.000), while 1 with IQR of 0.75-2 and 0 with IQR of 0-1.125 in the normal BBB permeability group (p = 0.006). (C) The albumin index was positively correlated to the CSF anti-AQP4-IgG titer (r = 0.351, p = 0.025). *p < 0.05, **p < 0.01, ***p < 0.001.