Fig. 3.

FTY dose-dependently reverses mechanical (A) and cold allodynia (B) in the CCI model. Mice were injected (i.p.) with vehicle or the indicated dose of FTY720 and tested for force threshold to induce paw withdrawal in response to von Frey filament application (A) or duration of paw lifting in response to acetone application (B) to the paw contralateral (Contra) or ipsilateral to the nerve injury. Data are expressed as mean ± S.E.M., n = 8 mice/group. Contralateral data shown are from mice injected with vehicle. Closed symbols indicate that the measurement is P < 0.05 different from the ipsilateral paw response in vehicle-injected mice. *P < 0.05 different from contralateral paw response in vehicle-injected mice.