Fig. 4.

FTY720 reverses allodynia for at least 6 hours in the CCI model. Mice were injected (i.p.) with vehicle or FTY720 (12 mg/kg) and tested for force threshold to induce paw withdrawal in response to von Frey filament application (A) or duration of paw lifting in response to acetone application (B) to the paw contralateral (Contra) or ipsilateral to the nerve injury. Data are expressed as mean ± S.E.M., n = 12 mice/group. Closed symbols indicate that the measurement is P < 0.05 different from the ipsilateral paw response in vehicle-injected mice at the indicated time point.