TABLE 1.

Effects of repeated FTY720 administration on the in vivo effects of FTY720 in mice

Values are mean ± S.E.M. of prolongation of tail–flick latency (% maximum possible effect), net change in rectal temperature (°C), ring immobility time (seconds), and spontaneous activity (beam breaks).

Treatment	Tail–Flick	Temperature	Immobility	Activity
Vehicle–Vehicle	8 ± 3	0.0 ± 0.3	10 ± 5	404 ± 33
Vehicle–FTY720	50 ± 10*	−2.8 ± 0.1*	72 ± 5*	148 ± 30*
FTY720–FTY720	14 ± 2§	−1.1 ± 0.2§	12 ± 2§	329 ± 30§

^*P < 0.05 different from Veh-Veh.

^§P < 0.05 different from Veh-FTY.