Table 2.
Top 10 potential new ADEs detected from FAERS and EMR but not recorded in ADReCS.
| Drugs | ADE AAD ADE signals | OR | P-value | Bonferroni-corrected P-value |
|---|---|---|---|---|
| Sulfasalazine | Postoperative wound infection | 8.02 | 3.60E-14 | 1.44E-12 |
| Diskitis | 8.02 | 3.60E-14 | 1.44E-12 | |
| Delayed healing | 6.02 | 2.47E-18 | 9.88E-17 | |
| Organizing pneumonia | 4.01 | 3.82E-13 | 1.53E-11 | |
| Lymph node metastasis | 4.01 | 3.82E-13 | 1.53E-11 | |
| Finger infection | 4.01 | 3.82E-13 | 1.53E-11 | |
| Staphylococcus | 3.01 | 8.19E-05 | 0.003276 | |
| Foot ulcer | 2.67 | 0.00 | 0.00 | |
| Interstitial fibrosis | 2.51 | 6.93E-11 | 2.77E-09 | |
| Septic joint | 2.50 | 0.00 | 0.00 | |
| Leflunomide | Hospital acquired pneumonia | 22.11 | 1.23E-24 | 4.92E-23 |
| Polymicrobial infection | 14.04 | 1.23E-24 | 4.92E-23 | |
| Foot cellulitis | 14.04 | 0.01 | 0.40 | |
| Septic joint | 12.06 | 7.74E-23 | 3.10E-21 | |
| Klebsiella pneumoniae | 12.03 | 7.74E-23 | 3.10E-21 | |
| Furunculosis | 12.03 | 1.69E-20 | 6.76E-19 | |
| Pseudomonas pneumonia | 10.02 | 1.72E-26 | 6.88E-25 | |
| Hip dislocation | 9.03 | 7.05E-18 | 2.82E-16 | |
| Subtrochanteric fracture | 8.01 | 7.05E-18 | 2.82E-16 | |
| Perforated gastric ulcer | 8.01 | 0.02 | 0.80 | |
| Methotrexate | Lymphoproliferative disorder | 34.09 | 1.05E-12 | 4.20E-11 |
| Shoulder fracture | 16.02 | 2.19E-32 | 8.76E-31 | |
| Malignant melanoma in situ | 16.02 | 2.19E-32 | 8.76E-31 | |
| Bacterial pneumonia | 16.02 | 2.19E-32 | 8.76E-31 | |
| Hospital acquired pneumonia | 14.03 | 5.39E-07 | 2.16E-05 | |
| Varicella zoster | 14.02 | 2.05E-30 | 8.20E-29 | |
| B cell lymphoma | 12.04 | 0.01 | 0.40 | |
| Osteoporotic fracture | 12.02 | 0.00 | 0.00 | |
| Chest congestion | 12.02 | 0.00 | 0.00 | |
| Wrist injury | 12.01 | 1.47E-28 | 5.88E-27 | |
| Hydroxychloroquine | Postoperative infection | 12.01 | 7.51E-40 | 3.00E-38 |
| Rheumatoid arthropathy | 8.01 | 5.13E-43 | 2.05E-41 | |
| Metastatic carcinoma | 8.01 | 5.13E-43 | 2.05E-41 | |
| Hip dislocation | 8.01 | 5.13E-43 | 2.05E-41 | |
| SLE flare | 8.01 | 5.47E-34 | 2.19E-32 | |
| Lumbar fracture | 8.01 | 5.47E-34 | 2.19E-32 | |
| Injection site reactions | 8.01 | 5.47E-34 | 2.19E-32 | |
| Ghon complex | 8.01 | 5.47E-34 | 2.19E-32 | |
| Upper extremity edema | 5.00 | 2.30E-35 | 9.20E-34 | |
| Shoulder dislocation | 5.00 | 2.30E-35 | 9.20E-34 |