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. 2018 Aug 7;9:1094. doi: 10.3389/fphys.2018.01094

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Copyright © 2018 Parodi-Rullán, Chapa-Dubocq and Javadov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Known SIRT3 targets in cardiac mitochondria. Enzyme-targets of SIRT3 in the heart are shown in green. Activities of enzymes (shown in green) involved in the TCA cycle (aconitase, MDH, IDH2), ETC (complexes I and II), OXPHOS (complex V), FAO (LCAD), base excision repair system (OGG1), antioxidant enzymes (MnSOD), mPTP induction (CyP-D), and pyruvate oxidation (PDH) are regulated by SIRT3. CS, citrate synthase; CyP-D, cyclophilin D; FH, fumarate hydratase; GSR, NADPH-dependent glutathione reductase; IDH2, isocitrate dehydrogenase; KGDH, α-ketoglutarate dehydrogenase; LCAD, long-chain acyl-CoA dehydrogenase; MDH, malate dehydrogenase, MnSOD, Mg²⁺-dependent mitochondrial superoxide dismutase; OGG1, oxoguanine glycosylase; PDH, pyruvate dehydrogenase; SCS, succinyl CoA synthetase; SDH, succinate dehydrogenase.