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. 2018 Aug 7;9:1094. doi: 10.3389/fphys.2018.01094

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Copyright © 2018 Parodi-Rullán, Chapa-Dubocq and Javadov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic approaches to target SIRT3. SIRT3 activity can be modulated by an increase in NAD⁺ availability and through direct SIRT3 activation. SIRT3 activity prevents cardiac hypertrophy thereby inhibiting the development of HF. Possible nutritional supplements and compounds that increase SIRT3 activation are shown in blue. C12, 7-hydroxyl-3-(4′-metoxyphenyl) coumarin; CR, caloric restriction; HKL, honokiol; NAAD, nicotinic acid adenine dinucleotide; NAMN, nicotinic acid mononucleotide; NAM, nicotinamide; NAMPT, nicotinamide phosphoribosyltransferase; NMN, nicotinamide mononucleotide; NMNAT, nicotinamide mononucleotide adenylyltransferase; NR, nicotinamide ribose.