Table 3.
Spearman rank correlation coefficients.
Gene/Network/Clinic | nM_M | O_T | EMT | Yoshihara |
---|---|---|---|---|
ABCB2/ABCB3/ABCC4/HER2 | −0.01 | 0.02 | 0.08 | −0.19 |
ABCC2 | 0.02 | −0.01 | −0.01 | 0.06 |
ESR1 | −0.01 | 0.12 | −0.12 | −0.15 |
SLCO1B7 | 0.01 | 0.06 | 0.03 | 0.05 |
SLCO2A1 | −0.16 | 0.02 | −0.09 | 0.28 |
SLCO4C1 | −0.08 | 0.12 | 0.04 | −0.13 |
SLCO5A1 | −0.09 | −0.14 | 0.00 | −0.13 |
Age | −0.13 | 0.04 | 0.01 | 0.12 |
FIGO | −0.01 | −0.09 | −0.17 | 0.04 |
Residual tumor | −0.06 | 0.02 | 0.04 | 0.12 |
ABCA1 | −0.07 | 0.04 | −0.13 | 0.21 |
ABCB1 | −0.10 | 0.10 | 0.04 | 0.00 |
ABCC10 | 0.02 | 0.08 | 0.01 | 0.04 |
ESR2 | −0.04 | −0.05 | −0.15 | −0.26 |
HPGD | −0.18 | 0.08 | −0.07 | 0.13 |
PTGS2 | 0.01 | 0.00 | −0.12 | 0.05 |
PXR | −0.11 | 0.05 | −0.02 | −0.21 |
SLCO1A2 | −0.22 | −0.07 | −0.10 | −0.04 |
SLCO1B3 | 0.03 | 0.03 | 0.14 | 0.02 |
SLCO2B1/ABCC3 | −0.05 | 0.11 | −0.04 | 0.28 |
SLCO3A1 | −0.10 | 0.13 | −0.04 | −0.08 |
SLCO4A1 | 0.07 | 0.10 | 0.19 | −0.08 |
SLCO6A1 | 0.02 | −0.08 | −0.01 | −0.03 |
SULT1E1 | −0.06 | 0.11 | −0.06 | 0.02 |
Data are given for (i) gene expressions, the first principal components of the co-expression networks, and clinicopathological parameters with (ii) gene signatures indicating molecular characteristics: peritoneal spread types, non-miliary or miliary (nM_M), positive value: high expression with M spreading; putative tumor origin, ovarian or fallopian tube (O_T), positive value: high expression with T origin; the epithelial-mesenchymal status (EMT), positive value: high expression with a more epithelial characteristic; and the Yoshihara (Yosh) molecular sub-classification system, high expression with subclass 2. Gray labeled are those genes, which were selected by the grouped LASSO approach predicting corresponding molecular characteristic. Bold printed are all genes/networks not present in any predictive LASSO regression model.