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. 2018 Aug 7;9:842. doi: 10.3389/fphar.2018.00842

Table 3.

Spearman rank correlation coefficients.

Gene/Network/Clinic nM_M O_T EMT Yoshihara
ABCB2/ABCB3/ABCC4/HER2 −0.01 0.02 0.08 −0.19
ABCC2 0.02 −0.01 −0.01 0.06
ESR1 −0.01 0.12 −0.12 −0.15
SLCO1B7 0.01 0.06 0.03 0.05
SLCO2A1 −0.16 0.02 −0.09 0.28
SLCO4C1 −0.08 0.12 0.04 −0.13
SLCO5A1 −0.09 −0.14 0.00 −0.13
Age −0.13 0.04 0.01 0.12
FIGO −0.01 −0.09 −0.17 0.04
Residual tumor −0.06 0.02 0.04 0.12
ABCA1 −0.07 0.04 −0.13 0.21
ABCB1 −0.10 0.10 0.04 0.00
ABCC10 0.02 0.08 0.01 0.04
ESR2 −0.04 −0.05 −0.15 −0.26
HPGD −0.18 0.08 −0.07 0.13
PTGS2 0.01 0.00 −0.12 0.05
PXR −0.11 0.05 −0.02 −0.21
SLCO1A2 −0.22 −0.07 −0.10 −0.04
SLCO1B3 0.03 0.03 0.14 0.02
SLCO2B1/ABCC3 −0.05 0.11 −0.04 0.28
SLCO3A1 −0.10 0.13 −0.04 −0.08
SLCO4A1 0.07 0.10 0.19 −0.08
SLCO6A1 0.02 −0.08 −0.01 −0.03
SULT1E1 −0.06 0.11 −0.06 0.02

Data are given for (i) gene expressions, the first principal components of the co-expression networks, and clinicopathological parameters with (ii) gene signatures indicating molecular characteristics: peritoneal spread types, non-miliary or miliary (nM_M), positive value: high expression with M spreading; putative tumor origin, ovarian or fallopian tube (O_T), positive value: high expression with T origin; the epithelial-mesenchymal status (EMT), positive value: high expression with a more epithelial characteristic; and the Yoshihara (Yosh) molecular sub-classification system, high expression with subclass 2. Gray labeled are those genes, which were selected by the grouped LASSO approach predicting corresponding molecular characteristic. Bold printed are all genes/networks not present in any predictive LASSO regression model.