Figure 3.

Overexpression of IGF1R inhibited apoptosis and promoted survival in glioblastoma multiforme cells. (A) Expression of IGF1R was upregulated by transfection with an IGF1R overexpression vector in U87 cells. (B) Overexpression of IGF1R reversed the decrease in cell viability induced by H₂O₂. (C) H₂O₂-induced cell death was attenuated by overexpression of IGF1R. (D) Activation of caspase-3 induced by H₂O₂ was suppressed by IGF1R overexpression. Data are presented as the mean ± standard error of the mean of three independent experiments. *P<0.05. IGF1R, insulin-like growth factor 1 receptor; U87, glioblastoma multiforme cell line.