Table II.
Significantly downregulated genes in hypertrophic chondrocytes treated with 3-morpholinosydnonimine.
| No. | ID | Symbol | Description | Fold regulation |
|---|---|---|---|---|
| 1 | NM_013465 | Ahsg | α-2-HS-glycoprotein | −6.19 |
| 2 | NM_007553 | BMP2 | Bone morphogenetic protein 2 | −6.11 |
| 3 | NM_173404 | BMP3 | Bone morphogenetic protein 3 | −8.52 |
| 4 | NM_009758 | BMPR1a | Bone morphogenetic protein receptor, type 1A | −4.17 |
| 5 | NM_007560 | BMPR1b | Bone morphogenetic protein receptor, type 1B | −7.16 |
| 6 | NM_007643 | Cd36 | Cluster of differentiation 36 antigen | −7.26 |
| 7 | NM_009866 | Cdh11 | Cadherin 11 | −3.05 |
| 8 | NM_009893 | Chrd | Chordin | −5.28 |
| 9 | NM_009925 | Col10a1 | Collagen, type X, α 1 | −4.03 |
| 10 | NM_016685 | Comp | Cartilage oligomeric matrix protein | −5.17 |
| 11 | NM_007802 | Ctsk | Cathepsin K | −3.14 |
| 12 | NM_010197 | Fgf1 | Fibroblast growth factor 1 | −7.89 |
| 13 | NM_010206 | Fgfr1 | Fibroblast growth factor receptor 1 | −11.16 |
| 14 | NM_010207 | Fgfr2 | Fibroblast growth factor receptor 2 | −3.34 |
| 15 | NM_010228 | Flt1 | FMS-like tyrosine kinase 1 | −7.41 |
| 16 | NM_010512 | Igf1 | Insulin-like growth factor 1 | −3.48 |
| 17 | NM_008396 | Itga2 | Integrin α 2 | −4.76 |
| 18 | NM_008402 | Itgav | Integrin α V | −7.52 |
| 19 | NM_010578 | Itgb1 | Integrin β 1 (fibronectin receptor β) | −4.20 |
| 20 | NM_019471 | MMP10 | Matrix metalloproteinase 10 | −45.25 |
| 21 | NM_008610 | MMP2 | Matrix metalloproteinase 2 | −3.66 |
| 22 | NM_013599 | MMP9 | Matrix metalloproteinase 9 | −4.66 |
| 23 | NM_008689 | Nfkb1 | Nuclear factor of κ light polypeptide gene enhancer in B cells 1, p105 | −3.66 |
| 24 | NM_011077 | Phex | Phosphate regulating gene with homologies to endopeptidases on the X chromosome | −4.44 |
| 25 | NM_008539 | Smad1 | Mothers against decapentaplegic homolog 1 (Drosophila) | −3.89 |
| 26 | NM_010754 | Smad2 | Mothers against decapentaplegic homolog 2 (Drosophila) | −3.10 |
| 27 | NM_016769 | Smad3 | Mothers against decapentaplegic homolog 3 (Drosophila) | −4.63 |
| 28 | NM_008540 | Smad4 | Mothers against decapentaplegic homolog 4 (Drosophila) | −4.17 |
| 29 | NM_009367 | Tgfb2 | Transforming growth factor, β 2 | −5.31 |
| 30 | NM_009370 | Tgfbr1 | Transforming growth factor, β receptor I | −16.00 |
| 31 | NM_009371 | Tgfbr2 | Transforming growth factor, β receptor II | −5.70 |
| 32 | NM_013693 | Tnf | Tumor necrosis factor | −9.19 |
| 33 | NM_011613 | Tnfsf11 | Tumor necrosis factor (ligand) superfamily, member 11 | −4.14 |
| 34 | NM_011693 | Vcam1 | Vascular cell adhesion molecule 1 | −6.68 |
Differentially expressed genes that were deemed differentially expressed by 3-fold or greater are presented.