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. 2018 Aug 7;9:873. doi: 10.3389/fphar.2018.00873

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Copyright © 2018 Xu, Zhang, Guo and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated plasma glycogen phosphorylase BB (GPBB) concentrations in high-grade glioma patients with TMZ resistance compared to those with TMZ sensitivity. Plasma GPBB concentration was measured before surgery. (A) Plasma GPBB concentration in toto, TMZ-sensitive and TMZ-resistant cohorts. (B) Plasma GPBB concentration in IDH1 mutant and IDH1 wild cohorts. (C) Plasma GPBB concentration in MGMT methylation and MGMT non-methylation cohorts. (D) Plasma GPBB concentration in 1p/19q co-deletion and 1p/19q wild cohorts. (E) ROC curve analysis of plasma GPBB concentration in response to TMZ. All values are expressed as means ± SEM, indicated by vertical bars. ^∗Indicates a statistically significant (P < 0.05) difference from TMZ-sensitivity group. (F) Survival curve showing overall survival (OS) for high-grade glioma patients with high levels or low levels of plasma GPBB.