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. 2018 Aug 7;9:873. doi: 10.3389/fphar.2018.00873

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Copyright © 2018 Xu, Zhang, Guo and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The upregulation of TMZ-induced Na,K-ATPase, ERK_1/2, and MGMT expression requires glycogenolysis in U251 cells. (A) Cells were incubated for 48 h in the absence of any drug (Control) or in the presence of 5 μM TMZ. In some experiments, 10 mM DAB, an inhibitor of glycogenolysis, was added 4 h before the addition of TMZ. (B1) Mean Akt expression was quantified as ratios between Akt and β-actin. (B2) Mean ERK_1/2 expression was quantified as ratios between ERK_1/2 and β-actin. (B3) Mean MGMT expression was quantified as ratios between MGMT and β-actin. Similar results were obtained from three independent experiments. SEM values are indicated by vertical bars. ^∗Indicates a statistically significant (P < 0.05) difference from the negative control group.