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. 2018 Aug 7;9:1089. doi: 10.3389/fphys.2018.01089

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Copyright © 2018 Sureshchandra, Marshall, Wilson, Barr, Rais, Purnell, Thornburg and Messaoudi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Obesity during pregnancy alters the placental transcriptome. (A) Principal Component Analysis of absolute gene expression of 500 most variable genes. (B) Functional enrichment of the 500 variable genes evaluated using DAVID. Numbers adjacent to the bar represent number of genes mapping to the gene ontology (GO) term. (C) Pie chart denoting number of differentially expressed genes (DEG) identified by edgeR with at least two-fold change in expression and FDR controlled at 5%. (D) Functional enrichment of 110 DEG using DAVID. Numbers adjacent to the bar represent number of DEGs mapping to the GO term (FDR < 5%). (E) Heatmap of genes mapping to disease terms “Immune System Diseases” and “Pregnancy Complications (FDR < 5%) (See Supplementary Figure 4A).