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. 2018 Jun 8;16(2):730–738. doi: 10.3892/etm.2018.6274

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Downregulation of ERK and AKT phosphorylation induced by anti-CYR-61. (A) Expression levels of ERK were analyzed using western blotting after treatment with anti-CYR-61. (B) Expression levels of AKT were analyzed by western blotting after treatment with anti-CYR-61. (C) Phosphorylation levels of ERK were analyzed in tumor sections following treatment with anti-CYR-61. Red arrows demonstrate positive pERK expression. (D) Phosphorylation levels of AKT were analyzed in tumor sections after treatment with anti-CYR-61. Red arrows demonstrate positive pAKT expression. Data are presented as the mean ± standard deviation of triplicate samples. **P<0.01 vs. the Control. ERK, extracellular signal-regulated kinase; AKT, protein kinase B; CYR-61, cysteine-rich angiogenic inducer-61; p, phosphorylated.