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. 2018 Jun 8;16(2):730–738. doi: 10.3892/etm.2018.6274

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of anti-CYR-61 on apoptosis in NSCLC cells. (A) Fluorescence-activated cell sorting was used to evaluate the apoptosis of H358 cells after anti-CYR-61 treatment. Apoptosis-related (B) mRNA and (C) protein expression levels in an exogenous cell apoptosis signaling pathway were analyzed in anti-CYR-61-treated cells. Apoptosis-related (D) mRNA and (E) protein expression levels in the mitochondrial apoptosis pathway were analyzed in anti-CYR-61-treated cells. Data are presented as the mean ± standard deviation of triplicate samples. **P<0.01 vs. the control. CYR-61, cysteine-rich angiogenic inducer-61; NSCLC, non-small-cell lung cancer; FasL, Fas ligand; FADD, Fas-associated protein with Death Domain; Bak, B cell lymphoma-2 antagonist/killer; Bax, B cell lymphoma-2-associated X protein; Apaf-1, apoptotic protease activating factor 1.