Table 2.
Characteristics of study samples in Senegal
| Group 1 | Group 2 | Group 3 | ||
|---|---|---|---|---|
| HBeAg-positive cases | HBeAg-negative controls | High HBV DNA (≥ 106 IU/mL) cases | ||
| All | Women of childbearing age | |||
| Total number | 48 | 196 | 117 | 28 |
| Male sex (n, %) | 31 (64.6%) | 129 (65.8%) | 80 (68.4%) | 0 |
| Median age (years, IQR) | 29 (21–36) | 37 (31–47) | 33 (26–43) | 32 (29–40) |
| Positive HBeAg by CLIA (Architect) | 48 (100%) | 0 | 68 (58.1%) | 15 (53.6%) |
| Median HBeAg levels (log10 PEIU/mL, IQR) | 1.5 (0.4–2.4) | N/A | 1.9 (0.9–2.8)* | 1.7 (1.1–2.7)† |
| Median HBV DNA levels (log10 IU/mL, IQR) | 7.7 (6.8–8.5) | 3.1 (2.4–3.9) | 7.6 (6.9–8.4) | 7.4 (6.7–8.3) |
CLIA = chemiluminescent immunoassay; HBeAg = Hepatitis B e antigen; HBV = hepatitis B virus; N/A = not applicable; PEIU = Paul Ehrlich Institut unit; RDT = rapid diagnostic test.
*
Excluding 49 samples with negative HBeAg by the reference CLIA test.
†
Excluding 13 samples with negative HBeAg by the reference CLIA test.