Table 2.
Iron and inflammatory markers by HIV status
| HIV-uninfected | HIV-infected | P value* | |
|---|---|---|---|
| N | 52 | 138 | |
| Hemoglobin, g/L, mean (SD)†‡ | 140 (23) | 111 (27) | < 0.001 |
| Anemia, n (%)†§ | 10 (19.6) | 86 (65.2) | < 0.001 |
| Mean cell volume (fL/cell), mean (SD)†‡ | 85.1 (9.4) | 76.8 (12.7) | < 0.001 |
| Microcytic anemia, n (%)†§‖ | 5 (9.8) | 62 (47.0) | < 0.001 |
| Ferritin, μg/L, median (IQR)¶ | 27.6 (12.0–65.7) | 51.5 (17.8–166.1) | 0.007 |
| C-reactive protein, mg/L median (IQR)¶ | 0.5 (0.3–1.1) | 4.7 (0.9–26.1) | < 0.001 |
| Soluble transferrin receptor, mg/L, median (IQR)¶ | 4.2 (2.9–5.1) | 4.8 (3.5–7.4) | 0.003 |
| Hepcidin, ng/mL, median (IQR)¶# | 9.1 (0.7–19.8) | 10.2 (2.0–19.8) | 0.30 |
| ID by ferritin criteria, n (%)** | 14 (26.9) | 28 (20.3) | 0.33 |
| ID by sTfR criteria, n (%)†† | 3 (5.8) | 26 (18.8) | 0.03 |
ID = iron deficiency.
*
P value determined by t test for means, Wilcoxon rank–sum test for medians, and χ2 test for categorical outcomes.
†
N = 51 for HIV-uninfected and 132 for HIV-infected.
‡
SD = standard deviation.
§
Anemia defined as < 12 g/dL in women and < 13 g/dL in men.
‖
Microcytosis defines as < 80 fL/cell in women and < 81 fL/cell in men.
¶
IQR = interquartile range: 25th percentile, and 75th percentile.
#
N = 47 for HIV-uninfected and 95 for HIV-infected.
**
ID = ferritin < 15 μg/L.
††
ID = sTfR ≥ 8.3 mg/L.