Table 2.
Cohort characteristics and test performance
| Micro-confirmed TB (N = 98) | Probable TB (N = 47) | Asymptomatic household contacts (N = 105) | |
|---|---|---|---|
| Age (median and IQR) | 30 (21–37) | 9 (4–31) | 7 (4–11) |
| Gender (%F) | 53/98 (54%) | 26/47 (55%) | 65% |
| HIV status (%+) | 65/98 (66%) | 31/47 (65%) | 22% |
| Median CD4 count (IQR) | 114 (31–324) | 152 (31–378) | 1,030 (603–1,195) |
| Sputum Xpert results | 93/98 (94%) | 0/33 (0%) | NA |
| Sputum culture results* | 57/73 (78%) | 0/21 (0%) | NA |
| Median time stool collected after ATT initiation in days (IQR) | 6 (1–14) | 1 (0–13) | NA |
| Stool PCR results | 67/98 (68%) | 6/47 (12%) | 2/105 (1.9%) |
| Adults | |||
|---|---|---|---|
| Micro-confirmed TB (N = 87) | Probable TB (N = 19) | ||
| Age (median) | 32 (25–41) | 32 (25–41) | |
| HIV status (%+) | 60/87 (68%) | 18/19 (94%) | |
| Median CD4 count (IQR) | 116 (30–323) | 115 (29–320) | |
| Sputum Xpert results | 82/87 (94%) | 0/19 (0%) | |
| Sputum culture results* | 50/65 (77%) | 0/14 (0%) | |
| Median time stool collected after ATT initiation in days | 5 (0–14) | 6 (1–14) | |
| Stool PCR results | 61/87 (70%) | 4/19 (21%) | |
| Children | |||
|---|---|---|---|
| Micro-confirmed TB (N = 10) | Probable TB (N = 28) | ||
| Age (median and IQR) | 7 (3–10) | 6 (2–9) | |
| HIV status (%+) | 5/10 (50%) | 15/27 (55%) | |
| Median CD4 count (IQR) | 181 (28–543) | 214 (27–598) | |
| Sputum Xpert results | 10/10 (100%) | 0/27 (0%) | |
| Sputum culture results* | 6/7 (87%) | 0/23 (0%) | |
| Median time stool collected after ATT initiation in days | 1 (0–14) | 1 (1–13) | |
| Stool PCR results | 5/10 (50%) | 2/27 (7%) | |
ATT = antituberculosis treatment; PCR = polymerase chain reaction; TB = tuberculosis.
*
According to National Guidelines, respiratory samples for culture are sent only if Xpert is positive or an individual is started on ATT. Therefore, the samples are not sent at the same time.