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Effects of paeoniflorin on the expression of (A) MMP-1, (B) MMP-3, (C) MMP-13 and (D) TIMP-1. Chondrocytes were pretreated with 0, 25 or 50 µM paeoniflorin for 3 h, followed by stimulation with IL-1β (10 ng/ml) for 24 h. Gene expression was assessed using reverse transcription-quantitative polymerase chain reaction. *P<0.05 vs. IL-1β alone and #P<0.05 vs. negative control. MMP, matrix metalloproteinase; TIMP, tissue inhibitor of MMP; IL, interleukin.
