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. 2018 Aug 7;9:862. doi: 10.3389/fphar.2018.00862

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Copyright © 2018 Zhen, Shao, Luria, Li, Li, Xu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippocampal neuronal progenitors differentiated into adult neurons and glias in EphB2 KO mice (A,B), which were related to altered NMDA receptor 2B (NR2B), pCREB and BDNF levels (C,D). (A) Double immunostaining for BrdU and NeuN or GFAP of mouse hippocampal slices. (B) The composition of BrdU labeled cells in EphB2 KO mice and the WT littermates. (C,D) NR2B was increased, while pCREB and BDNF were decreases in the EphB2 KO mice. *P < 0.05, **P < 0.01, and ***P < 0.001, vs. the wild type group.