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NMDA receptor 2B mediated EphB2 deficiency-induced depression-like behaviors and memory impairment. Ro25-6981 reversed EphB2 deficiency-induced increased immobility in the forced swimming (A) and tail suspension tests (B). Ro25-6981 also reversed EphB2 deficiency-induced increased latency to the platform and decreased crossing numbers in the probe trials (C,D). *P < 0.05, **P < 0.01, and ***P < 0.001, vs. the wild type group.
