Table IV.
Enriched pathway terms of differentially expressed genes in the severe pneumonia patients accompanied with chronic obstructive pulmonary disease compared with the controls.
| Pathway ID | Description | P-value | Genes |
|---|---|---|---|
| Upregulated | |||
| hsa00500 | Starch and sucrose metabolism | 2.23E-03 | UGT2B17, AMY1C |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.82E-03 | UGT2B17, GSTM1 |
| hsa00982 | Drug metabolism-cytochrome P450 | 4.04E-03 | UGT2B17, GSTM1 |
| hsa00053 | Ascorbate and aldarate metabolism | 3.48E-02 | UGT2B17 |
| hsa05310 | Asthma | 4.13E-02 | HLA-DRB5 |
| hsa00040 | Pentose and glucuronate interconversions | 4.26E-02 | UGT2B17 |
| Downregulated | |||
| hsa00970 | Aminoacyl-tRNA biosynthesis | 5.87E-36 | TRNL1, TRNS2, TRNR, TRNV, TRNH, TRNC, |
| TRNN, TRNP, TRNY, TRNT, TRNG, TRNE, TRNQ, | |||
| TRNI, TRNF, TRNS1, TRNW, TRNA, TRND, | |||
| TRNK, TRNL2, TRNM | |||
| hsa05012 | Parkinson's disease | 3.63E-13 | COX1, COX2, COX3, ND1, ATP6, ND4L, ND4, |
| ATP8, ND3, ND2, CYTB, ND5, ND6 | |||
| hsa00190 | Oxidative phosphorylation | 4.43E-13 | COX1, COX2, COX3, ND1, ATP6, ND4L, ND4, |
| ATP8, ND3, ND2, CYTB, ND5, ND6 | |||
| hsa05010 | Alzheimer's disease | 5.47E-04 | COX1, COX2, COX3, ATP6, ATP8, CYTB |
| hsa05016 | Huntington's disease | 8.60E-04 | COX1, COX2, COX3, ATP6, ATP8, CYTB |
| hsa04260 | Cardiac muscle contraction | 1.28E-03 | COX1, COX2, COX3, CYTB |
| hsa01100 | Metabolic pathways | 1.63E-02 | COX1, COX2, COX3, ND1, ATP6, ND4L, ND4, |
| ATP8, ND3, ND2, CYTB, ND5, ND6 | |||