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. 2018 Jun 12;16(2):1499–1504. doi: 10.3892/etm.2018.6296

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Figure 4. — PIK3CA was a direct target of miR-202. (A) The seed sequences for miR-202 in the 3′-UTR of PIK3CA revealed by TargetScan analysis. (B) Luciferase reporter assay was performed 48 h after co-transfection in DU145 cells with WT-PIK3CA or Mut-PIK3CA vectors together with miR-202 or negative control. (C) qRT-PCR revealed the effects of miR-202 mimics on the expression level of PIK3CA mRNA. (D) Western blot analysis revealed the effects of miR-202 mimics on the expression level of PIK3CA protein. (E) Relative expression of PIK3CA in prostate cancer tissues and adjacent normal tissues by qRT-PCR. (F) Expression correlation between miR-202 and PIK3CA in prostate cancer tissues. **P<0.01 and ***P<0.001 vs. the control group. PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α.