Table I.

GO analysis of differentially expressed genes in esophageal squamous cell carcinoma.

A, Upregulated genes in the category cellular component
GO term	Function	N (%)	P-value
GO:0031988	Membrane-bound vesicle	33 (0.25)	4.02×10−8
GO:0070062	Extracellular exosome	29 (0.22)	1.27×10−7
GO:1903561	Extracellular vesicle	29 (0.22)	1.45×10−7
GO:0043230	Extracellular organelle	29 (0.22)	1.46×10−7
GO:0044421	Extracellular region part	30 (0.23)	3.16×10−5
B, Downregulated genes
GO term	Function	N (%)	P-value
Biological process
GO:0006259	DNA metabolic process	17 (0.11)	1.81×10−7
GO:0051276	Chromosome organization	17 (0.11)	1.33×10−6
GO:0010564	Regulation of cell cycle process	12 (0.08)	7.36×10−6
GO:1903047	Mitotic cell cycle process	12 (0.08)	2.68×10−5
Cellular component
GO:0005694	Chromosome	20 (0.13)	2.80×10−8
GO:0044427	Chromosomal part	19 (0.12)	4.98×10−8
GO:0098687	Chromosomal region	11 (0.07)	1.35×10−6
GO:0000228	Nuclear chromosome	14 (0.09)	1.78×10−6
GO:0000793	Condensed chromosome	8 (0.05)	1.00×10−5
GO:0044454	Nuclear chromosome part	12 (0.08)	3.14×10−5
Molecular function
GO:0000166	Nucleotide binding	27 (0.17)	6.38×10−6
GO:1901265	Nucleoside phosphate binding	27 (0.17)	6.38×10−6
GO:0035639	Purine ribonucleoside triphosphate binding	23 (0.15)	1.03×10−5
GO:0032550	Purine ribonucleoside binding	23 (0.15)	1.08×10−5
GO:0001883	Purine nucleoside binding	23 (0.15)	1.09×10−5
GO:0032549	Ribonucleoside binding	23 (0.15)	1.12×10−5
GO:0001882	Nucleoside binding	23 (0.15)	1.18×10−5
GO:0032555	Purine ribonucleotide binding	23 (0.15)	1.41×10−5
GO:1901363	Heterocyclic compound binding	44 (0.28)	1.48×10−5
GO:0017076	Purine nucleotide binding	23 (0.15)	1.50×10−5
GO:0032553	Ribonucleotide binding	23 (0.15)	1.62×10−5
GO:0005524	ATP binding	20 (0.13)	1.70×10−5
GO:0036094	Small molecule binding	27 (0.17)	1.97×10−5
GO:0097159	Organic cyclic compound binding	44 (0.28)	2.02×10−5
GO:0032559	Adenyl ribonucleotide binding	20 (0.13)	2.15×10−5
GO:0030554	Adenyl nucleotide binding	20 (0.13)	2.28×10−5

GO, Gene Ontology.