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. 2018 May 24;16(2):585–594. doi: 10.3892/etm.2018.6217

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Copyright: © Shu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Changes of kidney structure and function in pregnant rats (GD20). (A-C) Histopathological images of glomeruli in pregnant rats of (A) the control group, (B) the 9D ML group and (C) the 10D ML group (H&E; magnification, ×400; scale bar, 25 µm). Black arrows indicate glomeruli. (D) The 24-h urine protein of the pregnant rats in GD20. **P<0.05 vs. control group; ^##P<0.05 9D ML group vs. 9D LL group; ^&&P<0.05 9D ML group vs. 10D LL group; ^&&P<0.05 9D ML group vs. 10D ML group. Values are expressed as the mean ± standard deviation. Groups: 9D LL, rats treated with low-dose L-NAME (40 mg/kg body weight/day) starting from at GD 9; 9D ML, rats treated with medium-L-NAME (75 mg/kg body weight/day) starting from GD 9; 9D HL, rats treated with high-dose L-NAME (125 mg/kg body weight/day) starting from GD 9; 10D LL, rats treated with low-dose L-NAME (40 mg/kg body weight/day) starting from GD 10; 10D ML, rats treated with medium-L-NAME (75 mg/kg body weight/day) starting from GD 10; 10D HL, rats treated with high-dose L-NAME (125 mg/kg body weight/day) starting from GD 10; control, normal pregnancy group. GD, gestational day; L-NAME, N-nitro-L-arginine methyl ester.