Table 1.
Some reported cellular mechanoresponse observed with myocyte and fibroblast. The focus here is the input and response, and detailed pathways should be found in each of the cited articles.
| Cell type | Input | Response | Reference |
|---|---|---|---|
| Cardiac myocyte | Mechanical stress | Increased hypertrophy | Kaye et al.23 |
| Skeletal muscle | Stretch | Increased hypertrophy | Perrone et al.24 |
| Skeletal muscle | Ramp stretch Ramp and cyclic stretch |
Myotube formation Increased proliferation |
Cheema et al.22 |
| Cardiac fibroblast | Deformation | Increased ECM synthesis | MacKenna et al.25 |
| Mesenchymal fibroblast | Principal strain Tension (stress) |
Alignment to direction Counteracting force generation Increased MMP-9 production |
Eastwood et al.26 |
| Dermal fibroblast | Tension (stress) | Increased ECM synthesis | Kessler et al.27 |
| Dermal fibroblast | Tension (stress) | Elevated proliferation rate | Kuang et al.28 |
ECM: extracellular matrix; MMP-9: matrix metallopeptidase 9.