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. 2018 May 18;7(8):569–582. doi: 10.1002/sctm.17-0267

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© 2018 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Modification of inflammatory profile in group with flap surgery and bone marrow‐derived mesenchymal stromal cell therapy. (A): Real‐time‐PCR analysis of TNF‐α and IL‐6. (B): Representative immunostaining for MAC387‐positive macrophages in the epidermis‐dermis and deep dermis of nonirradiated, irradiated on the day of surgery, and suture, flap, and flap‐MSC groups a year after surgery. Arrows indicated the presence of macrophages. Scale bars: 100 µm. Results are expressed as means ± SEM. p values were calculated by analysis of variance with Bonferroni correction, *, p < .01; **, p < .001 compared with nonirradiated controls; #, p < .05; ##, p < .01 compared with irradiated controls. Abbreviations: MSC, mesenchymal stromal cell; PCR, polymerase chain reaction.