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. 2018 May 18;7(8):569–582. doi: 10.1002/sctm.17-0267

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© 2018 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic diagram of wound healing of irradiated skin, according to treatment. The resection of fibrotic areas restarts fibroblastic activation and drives excess ECM production that produces a hypertrophic scar. Vascularized flap surgery generates an immature ECM, due to defective ECM protein production, and causes the persistence of inflammatory nodules and vessel loss. MSC therapy associated with the vascularized flap surgery provided durable repair by stabilizing fibroblast activation, thus helping to produce a mature ECM devoid of inflammation and leading to vascular stability. Abbreviations: ECM, extracellular matrix; MMP, matrix metalloproteinase; MSC, mesenchymal stromal cell.