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. 2018 Aug 10;9:3198. doi: 10.1038/s41467-018-05626-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — EGFR TKI-induced ALDH activity does not require MAML activity. a HCC827 (left) and HCC4006 (right) were stably infected with control vector or DN-MAML1 and treated with DMSO or erlotinib and subjected to ALDH assay. b HCC827 cells that were stably infected with control vector or DN-MAML1 were also treated stably infected with virus expressing notch operating promoter (NOP) reporter and NOP activity was assayed using FACS. c HCC827-Vector or HCC827-DN-MAML1 were grown on plates coated with DLL1-Fc chimera or control (PBS) for 48 h. Total RNA was isolated and HES1 expression was analyzed using qRT-PCR. For (a) and (c) error bars represent SD from biological triplicates. For (a) and (b) error bars represent SD from biological triplicates. For (c) error bars represent SD from technical triplicates