Table 1.

Relationship between the expression of HRNR and clinicopathological characteristics

Category	Subcategory	Cases	HRNR expression		P value
			Low (n = 114)	High (n = 157)
Gender	male	240	98	142
	female	31	16	15	0.826
Age (years)	≤ 50	131	56	75
	>  50	140	58	82	0.253
HCC family history	Yes	18	8	10
	No	253	106	147	0.665
HBsAg	negative	32	14	18
	positive	239	100	139	0.837
Child-pugh stage	A	269	113	156
	B	2	1	1	0.820
AFP(ng/ml)	< 20	67	22	45
	≥20	204	92	112	0.078
Edmonson Grading	I-II	212	96	116
	III-IV	59	18	41	0.042
Tumor Size (cm)	≤ 5	96	47	49
	>  5	175	67	108	0.089
Liver Cirrhosis	absent	55	27	28
	present	216	87	129	0.237
Capsulation	capsulated	171	76	95
	non-caspulated	100	38	62	0.300
Tumor Number	single	185	85	100
	multiple	86	29	57	0.058
Vascular Invasion	Yes	56	16	40
	No	215	98	117	0.022
TNM Stage	I-II	152	80	72
	III-IV	119	34	85	<  0.001

HRNR hornerin, HBsAg hepatitis B surface antigen, AFP alpha fetoprotein