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. 2018 Aug 13;18:114. doi: 10.1186/s12935-018-0612-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — a Detection of differences in PTEN expression in normal osteoblasts (hFOB 1.19) and osteosarcoma cell lines (MG-63, 143B, Saos-2 and UMR-106). b Detection of differences in PTEN expression between osteosarcoma and para-carcinoma tissues by qRT-PCR. After overexpression of PTEN in MG-63 (c) and 143B cells (d), proliferation is significantly decreased. e There is a negative correlation between miR-524 and PTEN expression levels in osteosarcoma tissues (n = 20) (***P < 0.001, **P < 0.01, *P < 0.05)