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. 2018 Aug 13;18:813. doi: 10.1186/s12885-018-4724-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Higher levels of CREB3L1 expression in TNBC demonstrate an improved response to doxorubicin-based chemotherapy. a A student t-test (two tailed, two sample unequal variance) was performed to compare CREB3L1 IRS values in tumors responded to doxorubicin-based chemotherapy (RCB Class 0-2, responder) versus those resisted the treatment (RCB Class 3, non-responder). b Pearson analysis was performed to determine the correlation between CREB3L1 IRS values and RCB scores of the tumors. The hollow dot indicates two samples at the same location on the plot. c Percentage of cases with indicated RCB class in tumors with lower expression of CREB3L1 (IRS value 0-3) and those with higher expression of the protein (IRS value 4-12)