Table 4.
Stratification analyses of H19 polymorphisms (rs217727) and risk of LC
| Pathological types | Case, n (%) | Control, n (%) | Crude OR, (95%CI) | P value | Adjusted OR, (95%CI)a | Pa value |
|---|---|---|---|---|---|---|
| Squamous Cells Carcinoma | ||||||
| G/G | 81 (37.7) | 217 (41.6) | 1.0 (ref.) | 1.0 (ref.) | ||
| A/G | 94 (43.7) | 252 (48.3) | 0.999 (0.705~ 1.416) | 0.997 | 0.790 (0.532~ 1.174) | 0.244 |
| A/A | 40 (18.6) | 53 (10.1) | 2.022 (1.247~ 3.279) | 0.004 | 1.996 (1.142~ 3.489) | 0.015 |
| A/G + A/A | 134 (62.3) | 305 (58.4) | 1.177 (0.849~ 1.631) | 0.327 | 0.977 (0.675~ 1.414) | 0.903 |
| Adenocarcinoma | ||||||
| G/G | 97 (39.1) | 228 (40.1) | 1.0 (ref.) | 1.0 (ref.) | ||
| A/G | 110 (44.4) | 281 (49.4) | 0.920 (0.665~ 1.272) | 0.615 | 0.904 (0.647~ 1.262) | 0.552 |
| A/A | 41 (16.5) | 60 (10.5) | 1.606 (1.011~ 2.551) | 0.045 | 1.767 (1.096~ 2.850) | 0.019 |
| A/G + A/A | 151 (60.9) | 341 (59.9) | 1.041 (0.767~ 1.412) | 0.797 | 1.047 (0.765~ 1.433) | 0.776 |
| Small Cell Carcinoma | ||||||
| G/G | 32 (34.8) | 187 (41.6) | 1.0 (ref.) | 1.0 (ref.) | ||
| A/G | 46 (50.0) | 216 (48) | 1.245 (0.761~ 2.035) | 0.383 | 1.114 (0.680~ 1.926) | 0.612 |
| A/A | 14 (15.2) | 47 (10.4) | 1.741 (0.860~ 3.522) | 0.123 | 1.799 (0.846~ 3.827) | 0.127 |
| A/G + A/A | 60 (65.2) | 263 (58.4) | 1.333 (0.835~ 2.129) | 0.229 | 1.253 (0.764~ 2.056) | 0.372 |
The bold values indicate statistical significance (P < 0.05)
LC lung cancer, OR odds ratio, CI confidence interval
a Adjusted for smoking status