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. 2018 Aug 6;19:148. doi: 10.1186/s12931-018-0837-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Lipogenic versus myogenic fibroblast phenotype. Lipogenic (lipofibroblast) and myogenic (myofibroblast) fibroblasts differentiate during early lung development and the saccular stage. Lipofibrobasts support alveolar epithelial type II cells (AECII) cell function via an intercellular crosstalk mediated by stretch, parathyroid hormone-related peptide (PTHRP), prostaglandin E2 (PGE2) and leptin while myofibroblasts produce extracellular matrix molecules such as elastin. Activation of peroxisome proliferator activated receptor (PPAR)γ by Rosiglitazone promotes the lipogenic phenotype. Stretch and transforming growth factor (TGF)-β induce the myogenic phenotype