. 2018 Aug 6;19:149. doi: 10.1186/s12931-018-0846-4

Table 3.

Receptor mechanisms of select neuropeptides

Neuropeptide	Receptor	Effectors & signaling molecules involved
Substance P/ Neurokinin A	neurokinin-1,2 & 3 receptors (NK-1,2 &3) (discussed and reviewed in [239] and [240]).	G_s and G_q [241-243]. ↑ intracellular Ca²⁺, DAG, cAMP, IP3 [79, 239, 244-246]. CFTR has been implicated [100].
VIP	VPAC1, VPAC2 and PAC1 [30, 247].	G_s, G_i and G_q [248, 249]. ↑ intracellular Ca²⁺, DAG, cAMP, IP3, [249]. CFTR has been implicated [132].
CGRP	CGRP-α subtype and CGRP-β subtype [31, 138, 250].	G_q and G_s [251]. ↑ intracellular Ca²⁺, DAG, IP3, cAMP [251, 252].
NPY	Y-1, Y-2, Y-4 and Y-5 receptors [32, 34, 182].	G_i and G_q [182, 253]. ↑ intracellular Ca²⁺, DAG, cAMP, IP3, [182, 253-256].
Bombesins (GRP-27; NMB)	NMB = subtype 1 receptor (BB₁); GRP-27 = subtype 2 receptor (BB₂); subtype-3 (BB₃) = orphan [35].	G_i and G_q [35]. ↑ intracellular Ca²⁺, DAG, cAMP, IP3 [35, 257].
Chromogranins (Secretoneurin)	Currently suspected, but not identified G-protein coupled receptor.	↑ intracellular Ca²⁺, cAMP [36].