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. 2018 Aug 13;18:127. doi: 10.1186/s12876-018-0850-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — MSCs suppressed the expressions of TNF-α, IFN-γ, IL-1β and IL-17A mRNA and proteins in the liver tissues of chronic DSS-induced colitis. a MSCs changed the expressions of TNF-α, IFN-γ, IL-1β and IL-17A mRNA in liver tissues of chronic colitis-associated hepatobiliary disorders. Data were expressed as mean ± SD. ^aP < 0.05 vs. the DSS + vehicle group; ^bP < 0.05 vs. the control group. b Representative western blots showing TNF-α, IFN-γ, IL-1β and IL-17A proteins expressions. c Expressions of TNF-α, IFN-γ, IL-1β and IL-17A staining in the DSS + vehicle group were higher than that of the control group, while in the DSS + MSCs group, these expressions decreased. d The expressions of the TNF-α, IFN-γ, IL-1β, and IL-17A protein in liver tissues were significantly increased in the DSS + vehicle group compared with that of the control group, while they were decreased in the DSS + MSCs group. e Quantification of cytokines by immunohistochemistry (original magnifications, × 400)