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. 2018 Aug 2;20:159. doi: 10.1186/s13075-018-1657-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The expression of proinflammatory mediators blocking ADAM-17 in RA FLSs. a ADAM-17 siRNA inhibited ADAM-17 expression in RA FLSs. b The expression of fractalkine/CX3CL1 was significantly decreased in TNF-α-stimulated ADAM-17 siRNA-transfected RA FLS-conditioned medium compared with TNF-α-stimulated control siRNA-transfected RA FLS-conditioned medium. (n = number of replicates). ADAM a disintegrin and metalloprotease family protein, FLSs fibroblast-like synoviocytes, siRNA small interfering RNA