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. 2018 Aug 2;37:180. doi: 10.1186/s13046-018-0833-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of KNG1 on the proteins associated with cell proliferation and apoptosis. a Protein levels of proliferation- and apoptosis-associated proteins were measured in U87-MG cells. b-c The expression of VEGF, CyclinD1 and ki67 were decreased by overexpressed KNG1. d-e The levels of caspase-3 and caspase-9 were enhanced while the XIAP expression was suppressed by overexpressed KNG1. f Changes of proliferation- and apoptosis-associated proteins were detected in SHG-44 cells. g-h The expression of VEGF, CyclinD1 and ki67 were inhibited by overexpressed KNG1. i-j The levels of caspase-3 and caspase-9 were increased while the XIAP expression was suppressed by overexpressed KNG1. The ns represents no significant difference; ^★P < 0.05 versus control