Fig. 1.

Correlation and coefficient of variation (CV) between both baseline samples taken between 1 and 7 d apart. (A) Relationship between log₁₀-transformed cfDNA concentration (ng/ml) at screening and at C1 in 507 paired samples derived from n = 571 patients. Correlation coefficient = 0.84 (Pearson's rho) with p < 0.001. (B) CV of baseline samples depicted in a frequency chart with mean and median CV of 0.12 and 0.08 with 95% CI of 0.11 and 0.13, respectively. Mean CV is shown in solid line. C = cycle; cfDNA = cell-free DNA; CI = confidence interval; CV = coefficient of variation.