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. 2018 Aug 2;17:113. doi: 10.1186/s12943-018-0862-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Correlation between HER2 and HER3 levels in human breast cancer. a Correlation of HER2 and HER3 mRNA expression in 80 primary human breast tumors. b-d Correlation of HER2 and HER3 mRNA (B) HER2 mRNA and HER3 protein levels c, HER2 and HER3gene copy-number d in breast invasive carcinoma (TCGA). e Meta-analysis of gene expression microarray data. miR-125a/b and miR-146a targets predicted by TargetScan (TS) were analyzed. The Pearson score of coexpression with HER2 mRNA of miR-125a/b targets was compared to miR-146a targets or all genes; the number of genes in each group is shown. f Meta-analysis of gene interaction with HER2. Genes targeted by the same miRNAs are circled. g A schematic model of HER2-HER3 mRNA cross-talk in breast tumor development and trastuzumab resistance