Table 3.
Treatment modality and complications of both groups according to kidney function in GUTB patients
| Variables | Normal kidney function group (n = 45) | CKD group (n = 11) | Total (n = 56) | p |
|---|---|---|---|---|
| Medical treatment | ||||
| TB medication use | 42 (93.3) | 11 (100.0) | 53 (94.6) | 0.894 |
| Medication regimen | 1.000 | |||
| HER | 6 (13.3) | 1 (9.1) | 7 (12.5) | |
| HERZ | 36 (80.0) | 10 (90.9) | 46 (82.1) | |
| Medication durations (m) | 9 (6–9) | 9 (9–10) | 9 (6–10) | 0.243 |
| Surgical treatment | ||||
| All surgical techniquesa | 32 (71.1) | 10 (90.9) | 42 (75.0) | 0.332 |
| Ablative surgeryb | 23 (51.5) | 8 (72.7) | 31 (55.4) | 0.340 |
| Nephrectomy | 11 (24.4) | 4 (36.4) | 15 (26.8) | 0.674 |
| Reconstructive therapyc | 12 (26.7) | 3 (27.3) | 15 (26.8) | 1.000 |
| Follow up durations (m) | 38.2 ± 27.8 | 48.0 ± 47.0 | 40.5 ± 32.5 | 0.362 |
| Complications | ||||
| Hydronephrosis | 9 (20.0) | 3 (27.3) | 12 (21.4) | 0.038 |
| Bladder contraction | 3 (6.7) | 2 (18.2) | 5 (8.9) | 0.021 |
| Renal calcification | 10 (22.2) | 3 (27.3) | 13 (23.2) | 0.044 |
| Additional surgical treatmentd | 9 (20.0) | 6 (54.5) | 15 (26.8) | 0.005 |
| Recurrence | 3 (6.7) | 1 (9.1) | 4 (7.1) | 0.056 |
| All cause mortality | 2 (4.4) | 2 (18.2) | 4 (7.1) | 0.132 |
| ESRD development | 0 (0.0) | 4 (36.4) | 4 (7.1) | 0.001 |
Bold values indicate statistically significant differences
Data were presented as mean ± SD, number (percentage) or median (IQR)
GUTB genitourinary tuberculosis, CKD chronic kidney disease, TB tuberculosis, HER isoniazid, rifampicin, and ethambutol, HERZ isoniazid, rifampicin, ethambutol, with pyrazinamide, ESRD end-stage renal disease, SD standard deviation, IQR interquartile range
aAll surgical techniques included all ablative surgery and reconstructive surgery from the time of diagnosis to completion of medical treatment
bAblative surgery is associated with partial or total nephrectomy, nephro-ureterectomy, cystectomy, epididymectomy, semicastration, salpingectomy, as well as other procedures
cReconstructive therapy is considered for: ureteric or urethral stricture repair; stent placement, replacement, or reimplantation; resection; urinary diversion; and bladder augmentation cystoplasty
dAny surgical treatment during follow up after completed medical treatment