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. 2018 Aug 7;8:301. doi: 10.3389/fonc.2018.00301

Figure 1.

Figure 1

Expression levels of BAFF, APRIL, BAFF-R, BCMA, and TACI in breast cancer cell lines and the effect of steroid hormones on APRIL expression levels (A). The expression of BAFF, APRIL, BAFF-R, BCMA, and TACI investigated by PCR in T47D and MDA-MB-231 cells breast cancer cell lines. Figure presents the results of a single experiment, while table shows the presence or absence of transcripts, based on three different experiments. See Material and Methods for further details and description of the controls. (B) APRIL expression [from data previously reported (20, 21)] and deposited in GEO under the numbers GSE18146, GSE32666, and GSE32668) after treatment of breast cancer cells for 3 h with steroid hormones, testosterone (Testo) or estradiol (E2), unconjugated or in their membrane impermeable form conjugated to BSA (steroid-BSA). See Material and Methods for details of data extraction and analysis. (C) Effect of testosterone-BSA (T-BSA) on APRIL expression (investigated by PCR) in T47D breast cancer cells in the presence or absence of cyproterone acetate (C) (*denotes p < 0.05).